Abstract presented at the Keystone Symposia on Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction in Keystone, CO in January, 2011:

Activation of SIRT1 by the Novel Small Molecule SRT2104 Protects against Diet-Induced Obesity and Improves Glucose Homeostasis by Increasing Fatty Acid and Carbohydrate Oxidation in Mice (oral presentation)

Abstract presented at the 2011 Cell Symposia: Metabolism & Aging in Cape Cod, MA in March 2011:

Metabolomic Analysis Reveals Profound Impact of SIRT1 Activators on Carbohydrate and Lipid Oxidation in Multiple Tissues
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Abstract presented at the 2011 ASBMB Meeting in Washington D.C. in April 2011:

SIRT1 activators promote p65 deacetylation and suppress TNFα stimulated NF-κB activation
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Abstracts presented at the 71st Scientific Sessions of the American Diabetes Association Meeting in San Diego, CA, in June 2011:

SRT2104, A Novel Small Molecule SIRT1 Activator Ameliorates High Fat Diet Induced Insulin Resistance, Promotes Glucose utilization by Enhancing Glycolysis and Increases both Carbohydrate and Lipid Oxidation in Mice
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The Metabolomic Profile of SRT2104, a Selective SIRT1 Activator in High Fat Diet Fed Mice Reveals Significant Improvements in Metabolic Function in Liver, Heart and Skeletal Muscle
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SIRT1-Mediated Regulation of FGF21 Expression in Lean Mice Probed with Small Molecule Activators and Genetic SIRT1 Deletion
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Abstracts presented at the 10th World Congress on Inflammation in Paris, France, in June 2011:

The First Demonstration of Clinical Activity by a Small Molecule SIRT1 Activator: SRT2104 Reduces Cytokine Release and Coagulation Activation in a Human Enotoxemia Model (oral presentation)

SRT2104, A Novel and Selective Small Molecule SIRT1 Activator, Inhibits DSS-induced Colitis in a SIRT1-Dependent Manner
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Abstracts presented at the FASEB Summer Conference on Histone Deacetylases and Reversible Acetylation in Signaling and Disease in Steamboat Springs, CO in June 2011:

The impact of small molecule SIRT1 activators on the DBC1-SIRT1 interaction
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Using the Connectivity Map to explore the mechanism of action of small molecule activators of the deacetylase SIRT1
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Abstract presented at the FASEB Summer conference on NAD Metabolism and Signaling in Lucca, Italy in September 2011:

Pharmacological SIRT1 Activation: Mechanism,Pharmacology and Experimental Medicine(invited oral presentation)

Abstract to be presented at the Keystone Symposia on Sirtuins in Metabolism, Aging and Disease in Tahoe City, CA in February 2012:

Therapeutic Application of SIRT1 Activators for the Treatment of Diseases of Aging (invited oral presentation)