Discovery
Sirtuin Platform
At Sirtris, our focus is on the sirtuins, a family of seven enzymes associated with the aging process. The discovery of the first human sirtuin, SIRT1, resulted from research into the health benefits and life extension seen in multiple species on calorie restricted diets. Rats, mice and dogs on calorie restricted diets are healthier and live longer.
Calorie restriction has been shown to activate SIRT1. Our goal is to mimic the beneficial effects of calorie restriction by developing small molecule SIRT1 activators.
Preclinical studies with SIRT1 activators have demonstrated potential importance in multiple disease areas, including Type 2 Diabetes and related complications, mitochondrial disorders, cardiovascular disease, inflammation, neurodegenerative diseases, and cancer. Early clinical studies have demonstrated promising results in Type 2 Diabetes.
While SIRT1 was the first in this family of enzymes to be discovered, considerable research is also underway for other members in this family, SIRTs 2-7. Their involvement in a variety of disease pathways suggests that the sirtuin family of enzymes represents an attractive portfolio of potential drug targets.
+  Potential Disease Area Applications
| Sirtuin |
Potential Disease Area Applications |
| SIRT1 |
Metabolic, neurological, mitochondrial, cancer, inflammation |
| SIRT2 |
Cancer, neurological, metabolic |
| SIRT3 |
Metabolic, mitochondrial, neurological, cardiovascular |
| SIRT4 |
Metabolic, mitochondrial |
| SIRT5 |
Metabolic |
| SIRT6 |
Inflammation, cancer, metabolic |
| SIRT7 |
Cardiovascular, metabolic |
Sirtris’ discovery efforts benefit from integrated teams focused on sirtuin biology, medicinal chemistry, clinical and translational medicine, and drug product process development and formulation. We have also formed important research partnerships with investigators in the academic community, sharing sirtuin modulators to develop new disease pathway knowledge. If you would like to partner with Sirtris in a research collaboration, please email collaboration@sirtrispharma.com.
|
