Dai H, Kustigian L, Carney D, Case A., Considine T, Hubbard B, Perni R, Riera T, Szczepankiewicz B, Vlasuk G, Stein R. SIRT1 activation by small molecules - kinetic and biophysical evidence for direct interaction of enzyme and activator. J. Biol. Chem. Epub 2010 August 11. 10.1074/jbc.M110.133892
View Publication

Yoshizaki T, Schenk S, Imamura T, Babendure JL, Sonoda N, Bae EJ, Oh da Y, Lu M, Milne JC, Westphal C, Bandyopadhyay G, Olefsky JM. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab. 2010; 298(3):E419-428. PMID: 19996381. [PubMed - indexed for MEDLINE]
View Publication

Elliott PJ, Walpole S, Morelli L, Lambert PD, Lunsmann W, Westphal CH, Lavu S Resveratrol/SIRT-501. Drugs of the Future. 2009; 34(4): 291.
View Publication

Vu CB, Milne JC, Carney DP, Song J, Choy W, Lambert PD, Gagne DJ, Hirsch M, Cote A, Davis M, Lainez E, Meade N, Normington K, Jirousek MR, Perni RB. Discovery of benzothiazole derivatives as efficacious and enterocyte-specific MTP inhibitors. Bioorg Med Chem Lett. 2009; 19(5):1416-1420. PMID: 19181526. [PubMed - indexed for MEDLINE]
View Publication

Nakamaru Y, Vuppusetty C, Wada H, Milne JC, Ito M, Rossios C, Elliot M, Hogg J, Kharitonov S, Goto H, Bemis JE, Elliott P, Barnes PJ, Ito K. A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J. 2009; 23(9):2810-2819. PMID: 19376817. [PubMed - indexed for MEDLINE]
View Publication

Jin L, Wei W, Jiang Y, Peng H, Cai J, Mao C, Dai H, Choy W, Bemis JE, Jirousek MR, Milne JC, Westphal CH, Perni RB. Crystal structures of human SIRT3 displaying substrate-induced conformational changes. J Biol Chem. 2009 Sept 4. Epub 2009 Jun 16. PMID: 19535340. [PubMed - indexed for MEDLINE]
View Publication

Bemis JE, Vu CB, Xie R, Nunes JJ, Ng PY, Disch JS, Milne JC, Carney DP, Lynch AV, Jin L, Smith JJ, Lavu S, Iffland A, Jirousek MR, Perni RB. Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators. Bioorg Med Chem Lett. 2009 April 15; 19:2350-2353. PMID: 19303289. [PubMed - indexed for MEDLINE]
View Publication

Smith JJ, Kenney RD, Gagne DJ, Frushour BP, Ladd W, Galonek HL, Israelian K, Song J, Razvadauskaite G, Lynch AV, Carney DP, Johnson RJ, Lavu S, Iffland A, Elliott PJ, Lambert PD, Elliston KO, Jirousek MR, Milne JC, Boss O. Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. BMC Syst Biol. 2009 Mar 10; 3:31. PMID: 19284563. [PubMed - indexed for MEDLINE]
View Publication

Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J. AMPK regulates energy expenditure by modulating NAD(+) metabolism and SIRT1 activity. Nature. Epub 2009 Mar 4. PMID: 19262508. [PubMed - indexed for MEDLINE]
View Publication

Yoshizaki T, Milne JC, Imamura T, Schenk S, Sonoda N, Babendure JL, Lu JC, Smith JJ, Jirousek MR, Olefsky JM. SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol, 2009 Mar; 29:1363-1374. PMID: 19103747. [PubMed - indexed for MEDLINE]
View Publication

Vu CB, Bemis JE, Disch JS, Ng PY, Nunes JJ, Milne JC, Carney DP, Lynch AV, Smith JJ, Lavu S, Lambert PD, Gagne DJ, Jirousek MR, Schenk S, Olefsky JM, Perni RB. Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators. J Med Chem. 2009 Feb; 52(5):1275-1283. PMID: 19199480. [PubMed - indexed for MEDLINE]
View Publication

Jin L, Galonek H, Israelian K, Choy W, Morrison M, Xia Y, Wang X, Xu Y, Yang Y, Smith JJ, Hoffmann E, Carney DP, Perni RB, Jirousek MR, Bemis JE, Milne JC, Sinclair DA, Westphal CH. Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3. Protein Sci. 2009 Jan 6; 18(3):514-525. PMID: 19241369. [PubMed - indexed for MEDLINE]
View Publication

Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA. SIRT1 Redistribution on Chromatin Promotes Genome Stability but Alters Gene Expression during Aging. Cell. 2008 Nov 28; 135(5): 907-18. PMID: 19041753. [PubMed - indexed for MEDLINE]
View Publication

Feige JN, Lagouge M, Canto C, Strehle A, Houten SM, Milne JC, Lambert PD, Mataki C, Elliott PJ, Auwerx J. Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation. Cell Metabolism. 2008 Nov 5; 8(5): 347-58. PMID: 19046567. [PubMed - indexed for MEDLINE]
View Publication

Szczepankiewicz BG, Ng PY. Sirtuin modulators: targets for metabolic diseases and beyond. Curr Top Med Chem. 2008 Nov; 8(17):1533-1544. PMID: 19075764. [PubMed - indexed for MEDLINE]
View Publication

Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates III J, Olefsky J, Guarente L, Montminy M. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature. 2008 Nov 13; 456: 269-73. Epub 2008 Oct 5. PMID: 18849969. [PubMed - indexed for MEDLINE]
View Publication

Lavu S, Boss O, Elliott PJ, Lambert PD. Sirtuins — novel therapeutic targets to treat age-associated diseases. Nat Rev Drug Discov. 2008 Oct 1; 7(10): 841-53. PMID: 18827827. [PubMed - indexed for MEDLINE]
View Publication

Pearson KJ, Baur JA, Lewis KN, Peskin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R. Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span. Cell Metabolism. 2008 Aug 6; 8(2): 157-68. Epub 2008 Jul 3. PMID: 18599363. [PubMed - indexed for MEDLINE]
View Publication

Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS ONE. 2008 Apr 16; 3(4):e2020. PMID: 18414679. [PubMed - indexed for Medline]
View Publication

Hallows WC, Albaugh BN, Denu JM. Where in the cell is SIRT3?--functional localization of an NAD+-dependent protein deacetylase. Biochem J. 2008 Apr 15; 411(2):e11-3. PMID: 18363549. [PubMed - indexed for MEDLINE]
View Publication

Elliott PJ, Jirousek M. Sirtuins: Novel targets for metabolic disease. Curr Opin Investig Drugs. 2008 Apr; 9(4):371-8. PMID: 18393104. [PubMed - indexed for Medline] View Publication Milne JC, Denu JM. The Sirtuin family: therapeutic targets to treat diseases of aging. Curr Opin Chem Biol. 2008 Feb; 12(1):11-7. Epub 2008 Mar 7. PMID: 18282481. [PubMed - indexed for Medline]
View Publication

Milne JC, Denu JM. The Sirtuin family: therapeutic targets to treat diseases of aging. Curr Opin Chem Biol. 2008 Feb; 12(1):11-7. Epub 2008 Mar 7. PMID: 18282481. [PubMed - indexed for Medline]
View Publication

Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29; 450(7170):712-6. PMID: 18046409. [PubMed - indexed for MEDLINE]
View Publication

Westphal CH, Dipp MA, Guarente L. A therapeutic role for sirtuins in diseases of aging? Trends Biochem Sci. 2007 Dec; 32(12):555-60. Epub 2007 Nov 5. PMID: 17980602. [PubMed - indexed for Medline]
View Publication

Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L. SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell. 2007 Oct 12; 28(1):91-106. PMID: 17936707. [PubMed - indexed for MEDLINE]
View Publication

Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV Jr, Weissman S, Verdin E, Schwer B. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007 Dec; 27(24):8807-14. Epub 2007 Oct 8. PMID: 17923681. [PubMed - indexed for MEDLINE]
View Publication

Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell. 2007 Sep 21;130(6):1095-107. PMID: 17889652. [PubMed - indexed for MEDLINE]
View Publication

Bordone L, Cohen D, Robinson A, Motta MC, van Veen E, Czopik A, Steele AD, Crowe H, Marmor S, Luo J, Gu W, Guarente L. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell. 2007 Dec; 6 (6):759-67. Epub 2007 Sep 17. PMID: 17877786. [PubMed - indexed for MEDLINE]
View Publication

Shindler KS, Ventura E, Rex TS, Elliott P, Rostami A. SIRT1 activation confers neuroprotection in experimental optic neuritis. Invest Ophthalmol Vis Sci. 2007 Aug; 48(8):3602-9. PMID: 17652729. [PubMed - indexed for MEDLINE]
View Publication

Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 2007 Jul 11; 26(13):3169-79. Epub 2007 Jun 21. PMID: 17581637. [PubMed - indexed for MEDLINE]
View Publication

Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 2007 Apr 4; 26(7):1913-23. Epub 2007 Mar 8. PMID: 17347648. [PubMed - indexed for MEDLINE]
View Publication

North BJ, Sinclair DA. Sirtuins: a conserved key unlocking AceCS activity. Trends Biochem Sci. 2007 Jan; 32(1):1-4. Epub 2006 Dec 1. PMID: 17141505. [PubMed - indexed for MEDLINE]
View Publication

Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006 Dec 15; 127(6):1109-22. Epub 2006 Nov 16. PMID: 17112576. [PubMed - indexed for MEDLINE]
View Publication

Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16; 444(7117):337-42. Epub 2006 Nov 1. PMID: 17086191. [PubMed - indexed for MEDLINE]
View Publication

Hallows WC, Lee S, Denu JM. Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci U S A. 2006 Jul 5; 103(27):10230-5. Epub 2006 Jun 21. PMID: 16790548. [PubMed - indexed for MEDLINE]
View Publication

Hallows WC, Lee S, Denu JM. Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci U S A. 2006 Jul 5; 103(27):10230-5. Epub 2006 Jun 21. PMID: 16790548. [PubMed - indexed for MEDLINE]
View Publication

Schwer B, Bunkenborg J, Verdin RO, Andersen JS, Verdin E. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A. 2006 Jul 5; 103(27):10224-9. Epub 2006 Jun 20. PMID: 16788062. [PubMed - indexed for MEDLINE]
View Publication

Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 2005 Mar 3; 434(7029):113-8. PMID: 15744310. [PubMed - indexed for MEDLINE]
View Publication

Araki T, Sasaki Y, Milbrandt J. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science. 2004 Aug 13; 305(5686):1010-3. PMID: 15310905. [PubMed - indexed for MEDLINE]
View Publication

Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. 2004 Aug 5;430(7000):686-9. Epub 2004 Jul 14. Erratum in: Nature. 2004 Sep 2; 431(7004):107. PMID: 15254550. [PubMed - indexed for MEDLINE]
View Publication

Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science. 2004 Jul 16; 305(5682):390-2. Epub 2004 Jun 17. PMID: 15205477. [PubMed - indexed for MEDLINE]
View Publication

Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De Oliveira R, Leid M, McBurney MW, Guarente L. SIRT1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature. 2004 Jun 17;429(6993):771-6. Epub 2004 Jun 2. Erratum in: Nature. 2004 Aug 19;430(7002):921. PMID: 15175761. [PubMed - indexed for MEDLINE]
View Publication

Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003 Sep 11; 425(6954):191-6. Epub 2003 Aug 24. PMID: 12939617. [PubMed - indexed for MEDLINE]
View Publication